Agent-enriched nanoparticles based on hydrophilic proteins

摘要

Disclosed is an active agent-loaded nanoparticles based on a hydrophilic protein or a combination of hydrophilic proteins, wherein said nanoparticles comprise at least one apolipoprotein which is bound to the hydrophilic protein or the hydrophilic proteins, via polyethylene glycol-alpha-maleimide-omega-NHS esters. Also disclosed is the method of producing the active agent loaded nanoparticles and the use of the nanoparticles in the manufacture of a composition to transport active agents across the blood-brain barrier.