发明名称 |
Human monoclonal antibodies against CD20 |
摘要 |
Disclosed are isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g ., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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申请公布号 |
NZ581541(A) |
申请公布日期 |
2011.07.29 |
申请号 |
NZ20030581541 |
申请日期 |
2003.10.17 |
申请人 |
GENMAB A/S |
发明人 |
RUULS, SIGRID;GLENNIE, MARTIN;TEELING, JESSICA;VAN DE WINKEL, JAN G J;PARREN, PAUL;PETERSEN, JORGEN;BAADSGAARD, OLE D M;HUANG, HAICHUN |
分类号 |
C12N5/24;C07K16/28;C07K16/30;C07K16/42;C12N5/22;C12N15/63 |
主分类号 |
C12N5/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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