QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS

摘要

Disclosed is a 1-azonia-bicyclo[2.2.2]octane selected from the group consisting by way of example; (R)-1-[(6-Methyl-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)5-1-azonia-bicyclo[2.2.2]octane X; (R)-1-[(6-Methyl-pyrazin-2-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane X wherein X represents a pharmaceutically acceptable anion of a mono or polyvalent acid. Also disclosed is the use of said compounds in the treatment of chronic obstructive pulmonary disease, a method of preparation.