ANTIBACTERIAL AND ANTIVIRAL PEPTIDES FROM ACTINOMADURA NAMIBIENSIS

摘要

Disclosed is a tryptophan, glycine and phenylalanine containing polypeptide of the formula (I) wherein R1 is H, alkyl; R2 is OH, amino , NH-alkyl, NH-alkylene-phenyl or NH-alkylene-pyridyl; R3 and R4 independently of each other H or OH, or R3 and R4 together are carbonyl; and m and n are independently of one another 0, 1 or 2; in any stereochemical form, or a mixture of any stereochemical forms in any ratio, or a physiologically tolerable salt thereof. Also disclosed is the use of said peptide for the treatment of bacterial infections, viral infections and/or pain, a pharmaceutical composition comprising at least one compound of the formula (I) and at least one pharmaceutically acceptable ingredient and a process for preparing a compound of the formula (I) according to any which comprises a) the strain Actinomadura namibiensis (DSM 6313), or one of its variants and/or mutants, being fermented under suitable conditions in a culture medium until one or more of the compounds of the formula (I) accrue(s) in the culture medium, b) a compound of the formula (I) being isolated from the culture medium, and c) the compound of the formula (I) being derivatized, where appropriate, and/or, where appropriate, being converted into a physiologically tolerated salt.