| 摘要 |
COMPOUNDS OF FORMULA (&Igr;): WHEREIN: R¹ IS HYDROXYMETHYL; R² IS SELECTED FROM —C(O)NR⁴R⁵, SO₂ NR⁴R⁵, -S(O)pR⁴ AND HET-2; HET-1 IS A 5- OR 6-MEMBERED, OPTIONALLY SUBSTITUTED C-LINKED HETEROARYL RING; HET-2 IS A 4-, 5- OR 6-MEMBERED, C- OR N-LINKED OPTIONALLY SUBSTITUTED HETEROCYCLYL RING; R³ IS SELECTED FROM HALO, FLUOROMETHYL, DIFLUOROMETHYL, TRIFLUOROMETHYL, METHYL, METHOXY AND CYANO; R⁴ IS SELECTED FROM FOR EXAMPLE HYDROGEN, OPTIONALLY SUBSTITUTED (1-4C)ALKYL AND HET-2; R⁵ IS HYDROGEN OR (1-4C)ALKYL; OR R⁴ AND R⁵ TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED MAY FORM A HETEROCYCLYL RING SYSTEM AS DEFINED BY HET-3; HET-3 IS FOR EXAMPLE AN OPTIONALLY SUBSTITUTED N-LINKED, 4, 5 OR 6 MEMBERED, SATURATED OR PARTIALLY UNSATURATED HETEROCYCLYL RING; P IS (INDEPENDENTLY AT EACH OCCURRENCE) 0, 1 OR 2; M IS 0,OR 1; N IS 0,1 OR 2;PROVIDED THAT WHEN M IS 0, THEN N IS 1 OR 2; OR A SALT, PRO-DRUG OR SOLVATE THEREOF, ARE DESCRIBED. THEIR USE AS GLK ACTIVATORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION ARE ALSO DESCRIBED.
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