摘要 |
Disclosed is a pyrimidine having the formula (I) or a pharmaceutically acceptable salt thereof, wherein each of Z1, Z2, and Z4 is, independently, CH or N, wherein at least one of Z1 or Z2 is N, R1, R2, JQ, JQ1 and JQ2 is defined in the specification. Also disclosed is the use of said compound for the treatment of allergic or type I hypersensitivity reactions, asthma, diabetes, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, amyotrophic lateralsclerosis, multiple sclerosis, schizophrenia, cardiomyocyte hypertrophy, reperfusion/ischemia, stroke, baldness, transplant rejection, graft versus host disease, rheumatoid arthritis, a solid malignancy, a hematologic malignancy, a leukemia, a lymphoma and a myeloproliferative disorder.
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申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
SALITURO, FRANSCESCO;FARMER, LUC;WANG, TIANSHENG;WANG, JIAN;BETHIEL, RANDY;WANNAMAKER, MARION;MARTINEZ-BOTELLA, GABRIEL;ARONOV, ALEXANDER;LAUFFER, DAVID;PIERCE, ALBERT;DUFFY, JOHN |