| 摘要 |
The application concerns an isolated protein complex comprising polypeptide components: (i) UTP20 HUMAN or a fragment, variant or homologue thereof; (ii) PWP2 HUMAN or a fragment, variant or homologue thereof; (iii) WDR46_HUMAN or a fragment, variant or homologue thereof; (iv) UTP18 HUMAN or a fragment, variant or homologue thereof; (v) MPPIO HUMAN or a fragment, variant or homologue thereof; (vi) WDR3_HUMAN or a fragment, variant or homologue thereof; (vii) TBL3 HUMAN or a fragment, variant or homologue thereof; (viii) WDR36_HUMAN or a fragment, variant or homologue thereof; and (ix) N0C4L HUMAN or a fragment, variant or homologue thereof. The application further concerns a method of identifying an agent that modulates the amount, function, activity, composition and/or formation of said protein complex; a method for the prevention or treatment of an eye disorder comprising administering to a subject in need thereof a suitable quantity of an agent that modulates the amount, function, activity, composition and/or formation of said protein complex; and a method of assessing whether a subject has or is likely to develop an eye disorder comprising determining whether the subject has an altered amount, function, activity, composition and/or formation of a protein complex.
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