发明名称 |
CAMPTOTHECIN DERIVATIVES AS CHEMORADIOSENSITIZING AGENTS |
摘要 |
Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.
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申请公布号 |
US2011184009(A1) |
申请公布日期 |
2011.07.28 |
申请号 |
US201113012772 |
申请日期 |
2011.01.24 |
申请人 |
SUTTER WEST BAY HOSPITALS, DBA CALIFORNIA PACIFICMEDICAL CENTER;CATHOLIC HEALTHCARE WEST DBA ST. MARY'S MEDICAL CENTER |
发明人 |
YANG LI-XI |
分类号 |
A61K31/4745;A61P35/00;C07D491/22 |
主分类号 |
A61K31/4745 |
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