COMPOSITIONS,KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF METABOLIC DISORDERS
摘要
The invention provides methods and compositions for selectively promoting anti- metabolic disorder activity over classical PPAR gamma activation through modulation of PPAR gamma phosphorylation (e.g., Ser-273 phosphorylation of murine peroxisome proliferator activated receptor gamma (PPAR gamma) 2 or a corresponding serine residue in a murine PPAR gamma 2 homolog, including a human). Also provided are methods for preventing, treating, or predictiving responsiveness of therapies for metabolic disorders in a subject through selective inhibition of such PPAR gamma phosphorylation. Further provided are methods for identifying compounds that are capable of modulating such PPAR gamma phosphorylation.
申请公布号
WO2011091134(A2)
申请公布日期
2011.07.28
申请号
WO2011US21855
申请日期
2011.01.20
申请人
DANA-FARBER CANCER INSTITUTE, INC.;SPIEGELMAN, BRUCE, M.;CHOI, JANG, HYUN;KAJIMURA, SHINGO;BANKS, ALEXANDER
发明人
SPIEGELMAN, BRUCE, M.;CHOI, JANG, HYUN;KAJIMURA, SHINGO;BANKS, ALEXANDER