INTERMEDIATES OF NEUTRAL ENDOPEPTIDASE INHIBITORS AND PREPARATION METHOD THEREOF

摘要

Disclosed are intermediates for the manufacture of neutral endopeptidase (NEP) inhibitors or prodrugs thereof, and preparation method thereof. In particular, the said NEP inhibitors comprise a ?-amino-d-biphenyl-a-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.