发明名称 |
Imaging Agents for Detecting Neurological Disorders |
摘要 |
Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and &bgr;-amyloid peptides are presented herein. The invention also relates to methods of imaging A&bgr; and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
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申请公布号 |
US2011182812(A1) |
申请公布日期 |
2011.07.28 |
申请号 |
US201113035405 |
申请日期 |
2011.02.25 |
申请人 |
SIEMENS MEDICAL SOLUTIONS USA, INC. |
发明人 |
SZARDENINGS ANNA KATRIN;ZHANG WEI;KOLB HARTMUTH C.;CASHION DANIEL KURT;CHEN GANG;KASI DHANALAKSHMI;LIU CHANGHUI;SINHA ANJANA;WANG ERIC;YU CHUL;GANGADHARMATH UMESH B.;WALSH JOSEPH C. |
分类号 |
A61K51/04;A61K49/00;A61P25/28;A61P43/00;C07D231/56;C07D401/04;C07D401/10;C07D413/14;C07D471/04;C07D487/04;C07D513/04 |
主分类号 |
A61K51/04 |
代理机构 |
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地址 |
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