发明名称 |
DIPEPTIDE-BASED PRODRUG LINKERS FOR AROMATIC AMINE-CONTAINING DRUGS |
摘要 |
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic amine group is conjugated to one or more polymeric carriers via dipeptide-containing linkers. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments. |
申请公布号 |
WO2011089215(A1) |
申请公布日期 |
2011.07.28 |
申请号 |
WO2011EP50820 |
申请日期 |
2011.01.21 |
申请人 |
ASCENDIS PHARMA AS;VETTER, DIRK;RAU, HARALD |
发明人 |
VETTER, DIRK;RAU, HARALD |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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