| 摘要 |
<p>In one aspect, the present invention provides for a compound of Formula I; in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.</p> |
| 申请人 |
GENENTECH, INC.;THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH;ABBOTT LABORATORIES |
发明人 |
BAELL, JONATHAN, BAYLDON;BUI, CHINH, THIEN;COLMAN, PETER;CZABOTAR, PETER;DUDLEY, DANETTE, A.;FAIRBROTHER, WAYNE, J.;FLYGARE, JOHN, A.;LESSENE, GUILLAUME, LAURENT;NDUBAKU, CHUDI;NIKOLAKOPOULOS, GEORGE;SLEEBS, BRAD, EDMUND;SMITH, BRIAN, JOHN;WATSON, KEITH, GEOFFREY;ELMORE, STEVEN, W.;HASVOLD, LISA, A.;PETROS, ANDREW, M.;SOUERS, ANDREW, J.;TAO, ZHI-FU;WANG, LE;WANG, XILU;DESHAYES, KURT |
