发明名称 |
SOLUTION PREPARATION CONTAINING STABILIZED ANTIBODY |
摘要 |
Disclosed is an antibody-containing solution preparation which does not undergo the production of conjugates when stored for a long period, is stable, and is suitable for subcutaneous administration. It is found that the use of a histidine buffer or aspartic acid or glutamic acid (which is an acidic amino acid) as a counter ion species for tris(hydroxymethyl)aminomethane, i.e., the use of a histidine-aspartate buffer or a histidine-glutamate buffer as a buffer or a tris(hydroxymethyl)aminomethane-aspartate or a tris(hydroxymethyl)aminomethane-glutamate exhibits a significant stabilizing effect. It is also found that the use of aspartic acid or glutamic acid (which is an acidic amino acid) as a counter ion species for a basic amino acid (e.g., arginine), i.e., the use of an arginine-aspartate or an arginine-glutamate exhibits a significant stabilizing effect. |
申请公布号 |
WO2011090088(A1) |
申请公布日期 |
2011.07.28 |
申请号 |
WO2011JP50911 |
申请日期 |
2011.01.20 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA;IGAWA, TOMOYUKI;MORIYAMA, CHIFUMI |
发明人 |
IGAWA, TOMOYUKI;MORIYAMA, CHIFUMI |
分类号 |
A61K39/00;A61K9/08;A61K9/19;A61K47/18;A61K47/26 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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