Multi-domain amphipathic helical peptides and methods of their use

摘要

Disclosed herein are peptides or peptide analogs with multiple amphipathicα-helical domains that promote lipid efflux from cells via an ABCAl-dependent pathway. Also provided herein are methods of using multi-domain amphipathicα-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.