发明名称 |
SOMATIC HYPERMUTATION SYSTEMS |
摘要 |
The present application relates to somatic hypermutation (SHM) systems and synthetic genes. Synthetic genes can be designed using computer-based approaches to increase or decrease susceptibility of a polynucleotide to somatic hypermutation. Genes of interest are inserted into the vectors and subjected to activation-induced cytidine deaminase to induce somatic hypermutation. Proteins or portions thereof encoded by the modified genes can be introduced into a SHM system for somatic hypermutation and proteins or portions thereof exhibiting a desired phenotype or function can be isolated for in vitro or in vivo diagnostic or therapeutic uses.
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申请公布号 |
US2011183855(A1) |
申请公布日期 |
2011.07.28 |
申请号 |
US20100972328 |
申请日期 |
2010.12.17 |
申请人 |
ANAPTYSBIO, INC. |
发明人 |
HORLICK ROBERT A.;CUBITT ANDREW B.;BOWERS PETER M. |
分类号 |
C40B10/00;C07K14/00;C07K14/195;C07K14/435;C07K14/52;C07K14/575;C07K16/00;C12N9/00 |
主分类号 |
C40B10/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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