发明名称 POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL) BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE
摘要 The invention relates to new crystalline Modifications of the hydrochloride of 1-[4-(5-cyanoin-dol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoin-dol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2 -carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.
申请公布号 US2011183994(A1) 申请公布日期 2011.07.28
申请号 US20100945260 申请日期 2010.11.12
申请人 发明人 BATHE ANDREAS;HELFERT BERND;NEUENFELD STEFFEN;KNIEL HEIKE;BARTELS MATTHIAS;RUDOLPH SUSANNE;BOETTCHER HENNING
分类号 A61K31/496;C07D405/00;A61P1/14;A61P3/04;A61P9/10;A61P9/12;A61P15/00;A61P15/10;A61P21/00;A61P25/00;A61P25/04;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P29/02;C07D403/14;C07D405/12 主分类号 A61K31/496
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