GASTRORETENTIVE SOLID ORAL DOSAGE FORMS WITH LIPID-BASED LOW-DENSITY EXCIPIENT

摘要

The disclosure provides multiparticulate systems that give release of active agents with a narrow window of absorption such that there is bioavailability to a patient. The disclosure provides a composition comprising microparticulates comprising a low density excipient and an active agent dispersed therein, wherein the ratio of low-density excipient to active agent is greater than 1:1.