| 摘要 |
PROBLEM TO BE SOLVED: To provide controlled release compositions with a high drug load, low burst effect upon administration, and minimum degradation of a bioactive agent. SOLUTION: The compositions are for use as controlled release therapeutics for the treatment of a wide variety of diseases. In particular, the compositions provide water-soluble bioactive agents, organic ions, and polymers where the bioactive agent is efficiently released over time with minimal degradation products. The resulting controlled release composition is capable of administration in a decreased dose volume due to the high drug content and predominance of non-degraded bioactive agent after release. Additionally, the compositions are capable of long-term sustained releases. COPYRIGHT: (C)2011,JPO&INPIT |
