发明名称 |
TREATING HEPATITIS C VIRUS INFECTION WITH OVER-EXPRESSION OF MICRORNA-196. |
摘要 |
<p>The present invention is directed to methods of treating cells infected with HCV and mammals suffering from HCV infection by transfecting the infected cells with miRNA-196 mimic. miRNA-196 mimic significantly down-regulates Bach1 protein and HCV gene expression, while also up-regulating HMOX1 gene expression. miRNA-196 binds with the 3'-UTR of Bach1 mRNA to reduce the expression of Bach1. As such, miRNA-196 can play an important role in the regulation of HCV replication and HMOX1/Bach1 expression in hepatocytes. The present invention also provides a formulation for the treatment of cells expressing HCV comprising a therapeutically effective amount of miRNA-196 such that Bach1 and HCV gene expression are down- regulated while HMOX1 expression is increased. The formulations are adapted to enable the transfection of miRNA-196 mimic into hepatocytes expressing HCV proteins.</p> |
申请公布号 |
MX2011003813(A) |
申请公布日期 |
2011.07.28 |
申请号 |
MX20110003813 |
申请日期 |
2009.10.08 |
申请人 |
CAROLINAS MEDICAL CENTER THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY D/B/A |
发明人 |
HERBERT L. BONKOVSKY;WEIHONG HOU |
分类号 |
C12N15/113;A61K31/713;A61P31/14 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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