发明名称 |
BLOOD TRANSCRIPTIONAL SIGNATURE OF MYCOBACTERIUM TUBERCULOSIS INFECTION. |
摘要 |
<p>The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with mycobacterium tuberculosis, and distinguishing such patients from uninfected individuals, the method including the steps of obtaining a gene expression dataset from a whole blood obtained sample from the patient and determining the differential expression of one or more transcriptional gene expression modules that distinguish between infected and non-infected patients, wherein the dataset demonstrates an aggregate change in the levels of polynucleotides in the one or more transcriptional gene expression modules as compared to matched non- infected patients, thereby distinguishing between active and latent mycobacterium tuberculosis infection.</p> |
申请公布号 |
MX2010014556(A) |
申请公布日期 |
2011.07.28 |
申请号 |
MX20100014556 |
申请日期 |
2009.06.25 |
申请人 |
BAYLOR RESEARCH INSTITUTE |
发明人 |
BANCHEREAU, JACQUES, F.;CHAUSSABEL, DAMIEN;O'GARRA, ANNE;BERRY, MATTHEW;KON ONN MIN |
分类号 |
G01N33/50;C12Q1/00;G01N33/53 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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