Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect

摘要

P:/OPER/MAL/2 /30546200 D, d-21I5/2nm Partially desulphated glycosaminoglycan derivatives are described, 5 particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. Said glycosaminoglycan derivatives are endowed with antiangiogenic and heparanase-inhibiting acitivity ans are devoid of anticoagulant activity.