发明名称 |
ACTIVATED NITRIC OXIDE DONORS AND METHODS OF MAKING AND USING THEREOF |
摘要 |
Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) an O2-aryl substituted diazeniumdiolate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. The compositions described herein provide numerous advantages such as increased solubility and stability of the O2-aryl substituted diazeniumdiolate in vivo. The compositions also do not induce hypotension. Methods for using the compositions in anticancer treatment and prevention are also described herein.
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申请公布号 |
US2011182978(A1) |
申请公布日期 |
2011.07.28 |
申请号 |
US20090921227 |
申请日期 |
2009.03.05 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
SHAMI PAUL J.;KOSAK KEN M. |
分类号 |
A61K9/127;A61K31/56;A61K31/655;A61K35/12;A61K38/22;A61K38/43;A61K39/395;A61P35/00;C12N5/071;C12N5/077 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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