发明名称 |
POLYPEPTIDE HETERODIMERS AND USES THEREOF |
摘要 |
The present disclosure provides polypeptide heterodimers formed between two different single chain fusion polypeptides via natural heterodimerization of an immunoglobulin CH1 region and an immunoglobulin light chain constant region (CL). One chain of a heterodimer comprises a binding domain that specifically binds a target (e.g., a receptor). In addition, both chains of a heterodimer further comprise an Fc region portion. The present disclosure also provides nucleic acids, vectors, host cells and methods for making polypeptide heterodimers as well as methods for using such polypeptide heterodimers, such as in reducing T cell activation, inhibiting solid malignancy growth, and treating autoimmune or inflammatory conditions. |
申请公布号 |
WO2011090754(A1) |
申请公布日期 |
2011.07.28 |
申请号 |
WO2010US62404 |
申请日期 |
2010.12.29 |
申请人 |
EMERGENT PRODUCT DEVELOPMENT SEATTLE, LLC;BLANKENSHIP, JOHN, W.;TAN, PHILIP |
发明人 |
BLANKENSHIP, JOHN, W.;TAN, PHILIP |
分类号 |
C07K16/46;A61K39/395;A61P35/00;A61P37/00 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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