摘要 |
A multivalent antibody fusion protein comprising: a heavy chain comprising, in sequence from the N-terminal, a variable domain nominally VH1, a CH1 region and a further variable domain nominally VH2, a light chain comprising, in sequence from the N-terminal, a variable domain nominally VL1, a CL domain and a variable domain nominally VL2, wherein said heavy and light chains are aligned to provide a first binding site formed by a first variable domain pair of VH1 and VL1 and a second binding site formed by a second variable domain pair of VH2 and VL2, and said fusion protein is conjugated to a PEG polymer. |
申请人 |
UCB PHARMA S.A.;HEYWOOD, SAM, PHILIP;HUMPHREYS, DAVID, PAUL;LAWSON, ALASTAIR, DAVID, GRIFFITHS |
发明人 |
HEYWOOD, SAM, PHILIP;HUMPHREYS, DAVID, PAUL;LAWSON, ALASTAIR, DAVID, GRIFFITHS |