<p>Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.</p>
申请公布号
SG172291(A1)
申请公布日期
2011.07.28
申请号
SG20110045283
申请日期
2009.12.18
申请人
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION