发明名称 |
DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO THE PANCREATIC ENDOCRINE LINEAGE |
摘要 |
The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependant kinase inhibitor to cause an increase in expression of MAFA. |
申请公布号 |
EP2346988(A1) |
申请公布日期 |
2011.07.27 |
申请号 |
EP20090752567 |
申请日期 |
2009.10.23 |
申请人 |
CENTOCOR ORTHO BIOTECH INC. |
发明人 |
REZANIA, ALIREZA;FRYER, BENJAMIN |
分类号 |
C12N5/071 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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