发明名称 |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
摘要 |
The Invention provides a method for producing a cytotoxic conjugate which comprises one or more maytansinoid molecules and a cell binding agent, said method consisting essentially of the single step of reacting one or more maytansinoid molecules containing a reactive ester with a cell binding agent. |
申请公布号 |
EP2348024(A2) |
申请公布日期 |
2011.07.27 |
申请号 |
EP20110003908 |
申请日期 |
2002.02.14 |
申请人 |
IMMUNOGEN, INC. |
发明人 |
CHARI, RAVI V.J.;WIDDISON, WAYNE C. |
分类号 |
C07D491/12;A61K31/537;A61K47/48;A61P35/00;A61P35/02;C07D498/18 |
主分类号 |
C07D491/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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