Bone delivery conjugates and method of using same to target proteins to bone

摘要

A bone delivery conjugate having a structure selected from the group consisting of :A) X-D n -Y-protein-Z; and B) Z-protein-Y- D n -X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and D n is a poly aspartate wherein n = 10 to 16. Compositions comprising same and uses thereof.