OLIGO(ETHYLENE GLYCOL) BASED GELATOR COMPRISING CYCLIC PEPTIDES AND ITS PREPARATION METHOD

摘要

PURPOSE: A method for preparing oligo(ethylene glycol) gelling agent containing cylic peptides is provided to ensure remarkable effect in gelation uniformity and time. CONSTITUTION: A gelling agent conjugated with cyclic peptides has a structure of chemical formula 1 or 2. A bio material contains the gelling agent. The bio material is a drug delivery system, bio sensor, cosmetic filling agent, cell culture medium, tissue engineering support, and chemical valve. A method for manufacturing the gelling agent of chemical formula 1 comprises: a step of coupling a compound of chemical formula 3 with a compound of chemical formula 4 to prepare a compound of chemical formula 5; a step of reacting the compound of chemical formula 5 with a compound of chemical formula 6 to prepare a compound of chemical formula 7; a step of deprotecting Boc protection group from the compound of chemical formula 7 to prepare a compound of chemical formula 8; and a step of cyclizing both end groups of the compound of chemical formula 8.