| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to a new maleate salt of 4-((4-fluorine-2-methyl-1H-indole-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidine-1-yl)propoxy)quinazoline in a crystalline form A or B which exhibit the improved use properties, particularly shows higher stability. The invention also concerns versions of methods of producing the maleate salt of 4-((4-fluorine-2-methyl-1H-indole-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidine-1-yl)propoxy)quinazoline in the crystalline form A or B, to a pharmaceutical composition containing them and to an application for preparing a drug used for producing an anticancer effect. ^ EFFECT: preparation of the compounds to be used for producing an antiangiogenic action and/or reducing a vascular permeability. ^ 14 cl, 3 ex, 5 tbl, 10 dwg |
