发明名称 |
PROPANE-1,3-DIONE DERIVATIVE OR SALT THEREOF |
摘要 |
It is intended to provide a compound useful as a GnRH receptor antagonist. The inventors further investigated propane-l,3-dione derivatives. As a result, they confirmed that a compound having a benzene ring or a thiophene ring substituted with a group represented by -S02-R3 in a propane-1,3-dione derivative having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene) has an excellent GnRH receptor antagonistic effect and accomplished the present invention. Because the compound of the present invention has a potent GnRH receptor antagonistic effect, it is useful for the treatment of sex hormone--dependent diseases, particularly GnRH-related diseases. Further, because the compound of the present invention has an excellent metabolic stability in human and few drug interactions, therefore it has preferable characteristics as a pharmaceutical used for the above-mentioned diseases.
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申请公布号 |
CA2603185(C) |
申请公布日期 |
2011.07.26 |
申请号 |
CA20062603185 |
申请日期 |
2006.03.30 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
HIRANO, MASAAKI;KINOYAMA, ISAO;MATSUMOTO, SHUNICHIRO;KAWAMINAMI, EIJI;OHNUKI, KEI;YAMAMOTO, HIROFUMI;OSODA, KAZUHIKO;TAKAHASHI, TATSUHISA;SHIN, TAKASHI;KOIKE, TAKANORI;SHIMADA, ITSURO;HISAMICHI, HIROYUKI;KUSAYAMA, TOSHIYUKI |
分类号 |
C07D235/12;A61K31/4184;A61K31/4192;A61K31/4196;A61K31/422;A61K31/427;A61K31/433;A61K31/4439;A61K31/454;A61K31/4725;A61K31/496;A61K31/497;A61K31/501;A61K31/506;A61K31/5377;A61K31/5415;A61P5/24;A61P13/08;A61P15/00;A61P35/00;A61P43/00;C07D401/06;C07D401/12;C07D403/12;C07D405/06;C07D405/12;C07D409/06;C07D409/12;C07D413/06;C07D413/12;C07D417/06;C07D417/12;C07D417/14 |
主分类号 |
C07D235/12 |
代理机构 |
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