发明名称 PROCESS FOR PRODUCING COMPOSITE PREPARATION CONTAINING NUCLEIC ACID
摘要 A process for producing a homogeneous nucleic-acid-containing composite preparation of good quality which is capable of sterilization by filtration and is characterized by containing no coarse particles having a size of 7 µm or larger, which are regarded as unsafe for the human body. The process for producing the preparation, containing a composite of a cationic carrier with a nucleic acid polymer, is characterized in that two single-stranded nucleic acid polymers capable of at least partly forming a double-stranded state are separately added, each in the single-stranded state, to either a cationic carrier or a material from which the cationic carrier is to be formed, and all these ingredients are subjected to a dispersing treatment.
申请公布号 CA2333162(C) 申请公布日期 2011.07.26
申请号 CA19992333162 申请日期 1999.05.24
申请人 NIPPON SHINYAKU CO., LTD. 发明人 SUGIHARA, KATSUHIRO;SEKI, JUNZO;HIRABAYASHI, KAZUKO
分类号 A61K31/7105;A61K48/00;A61K9/10;A61K9/19;A61K31/70;A61K31/7088;A61K31/711;A61K31/712;A61K47/16;A61P35/00;C07H21/00;C07H21/02 主分类号 A61K31/7105
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