| 发明名称 |
MODIFIED WITH POLYMER FACTOR VIII FOR THE TREATMENT OF HAEMOPHILIA AND PROCESS FOR THE PREPARATION THEREOF |
| 摘要 |
This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties. |
| 申请公布号 |
UA95225(C2) |
申请公布日期 |
2011.07.25 |
| 申请号 |
UA20070006559 |
申请日期 |
2005.11.14 |
| 申请人 |
BAYER HEALTHCARE LLC |
发明人 |
PAN CLARK Q.;MURPHY JOHN E.;MEI BAISONG;STRAUSS JONATHAN S.;TJANDRA HENDRI;CHEN JIANMIN;BARNETT THOMAS;TANG LIANG;WANG DEQIAN |
| 分类号 |
A61K38/37;A61K47/48;A61P7/04 |
主分类号 |
A61K38/37 |
| 代理机构 |
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