YEAST CELLS EXPRESSING AMYLOID BETA AND USES THEREFOR
摘要
Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease.
申请公布号
WO2011088059(A1)
申请公布日期
2011.07.21
申请号
WO2011US20879
申请日期
2011.01.11
申请人
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH;MATLACK, KENT E.S.;LINDQUIST, SUSAN L.