INDOLINE SCAFFOLD SHP-2 INHIBITORS AND METHOD OF TREATING CANCER
摘要
Protein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases that are involved in the pathogenesis of human carcinoma. A high throughput screen identified compounds that inhibit the PTP Shp2. Several compounds were identified that selectively inhibit Shp2 over Shp1 with low to sub-micromolar activity. Also disclosed are methods of inhibiting a protein tyrosine phosphatase in a cell and treating cancer through selective inhibition of Shp2.
申请公布号
WO2010121212(A3)
申请公布日期
2011.07.21
申请号
WO2010US31506
申请日期
2010.04.16
申请人
H. LEE MOFFIT CANCER CENTER AND RESEARCH INSTITUTE, INC.;UNIVERSITY OF SOUTH FLORIDA;WU, JIE;LAWRENCE, NICHOLAS, JAMES;SEBTI, SAID M.;LAWRENCE, HARSHANI, RITHMA
发明人
WU, JIE;LAWRENCE, NICHOLAS, JAMES;SEBTI, SAID M.;LAWRENCE, HARSHANI, RITHMA