发明名称 |
SILENCING OF CSN5 GENE EXPRESSION USING INTERFERING RNA |
摘要 |
The present invention provides compositions comprising nucleic acids that target CSN5 gene expression and methods of using such compositions to silence CSN5 gene expression. More particularly, the present invention provides unmodified and chemically modified interfering RNA molecules which silence CSN5 gene expression and methods of use thereof, e.g., for treating cell proliferative disorders such as cancer. The present invention also provides nucleic acid-lipid particles that target CSN5 gene expression comprising an interfering RNA molecule, a cationic lipid, a non-cationic lipid, and optionally a conjugated lipid that inhibits aggregation of particles.
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申请公布号 |
US2011178155(A1) |
申请公布日期 |
2011.07.21 |
申请号 |
US20100903558 |
申请日期 |
2010.10.13 |
申请人 |
PROTIVA BIOTHERAPEUTICS, INC.;THE USA, AS REPRESENTED BY THE SECRETARY, DEPT.OFHEALTH AND HUMAN SERVICES |
发明人 |
MACLACHLAN IAN;JUDGE ADAM;THORGEIRSSON SNORRI S.;LEE YUN-HAN |
分类号 |
A61K31/7105;A61P35/00;C07H21/02;C12N5/071;C12N15/113 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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