VARIANTS OF THE GROUP-5 ALLERGENS OF THE POACEAE WITH REDUCED ALLERGENICITY BY MUTAGENESIS OF PROLINE RESIDUES

摘要

The present invention relates to the preparation and the use of recombinant variants of the group-5 allergens of the poaceae which are characterized by the fact that their IgE reactivity is reduced in comparison with the known wild-type allergens while simultaneously the reactivity with T-lyphocytes is largely retained.