PROCESS FOR PRODUCTION OF N-ACETYL-D-NEURAMINIC ACID

摘要

Disclosed are: NANA aldolase which is stable under alkaline conditions having high pH values; and a process for producing NANA in a large amount with high efficiency using the NANA aldolase. Specifically disclosed are: a protein which exhibits pH stability at pH 8.0 to 11.0 and has an N-acetyl-D-neuraminic acid aldolase activity; a polynucleotide encoding the protein; an expression vector carrying the polynucleotide; a transformant having the expression vector introduced thereinto; a bacterium capable of producing the protein; a process for producing N-acetyl-D-neuraminic acid aldolase using the protein; and others.