发明名称 |
Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
摘要 |
Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic; hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
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申请公布号 |
US2011178161(A1) |
申请公布日期 |
2011.07.21 |
申请号 |
US20070982364 |
申请日期 |
2007.10.31 |
申请人 |
ANTISOMA RESEARCH LIMITED |
发明人 |
TRENT JOHN O.;BATES PAULA J.;MILLER DONALD M. |
分类号 |
A61K48/00;A61P35/00;C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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