| 摘要 |
The present invention relates to polypeptides, compositions, and methods of use thereof for optimized treatment of diseases or disorders associated with amyloid beta protein (Aβ) accumulation in a subject. This invention also relates to polypeptides, compositions, and methods of use thereof for optimized immunization against diseases characterized by Aβaccumulation in a subject. This invention further relates to pharmaceutical formulations comprising these polypeptides and methods of use for administering to a subject an optimized Aβpeptide that elicits a beneficial T cell response; for example, a T cell response reducing Aβaccumulation in the brain of a subject, without causing an encephalitic response.
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