INHIBITORS OF RECEPTOR TYROSINE KINASES (RTK) AND METHODS OF USE THEREOF
摘要
The present invention provides moieties that bind to the asymmetric contact interface of a receptor tyrosine kinase (RTK), wherein the moieties inhibit ligand induced trans autophosphorylation of the RTK. The present invention also provides methods of treating or preventing an RTK-associated disease and methods for identifying moieties that bind to an asymmetric contact interface of an RTK.
申请公布号
WO2011088196(A2)
申请公布日期
2011.07.21
申请号
WO2011US21109
申请日期
2011.01.13
申请人
YALE UNIVERSITY;BAE, JAE, HYUN;LAX, IRIT;SCHLESSINGER, JOSEPH