发明名称 |
INHIBITORS OF RECEPTOR TYROSINE KINASES (RTK) AND METHODS OF USE THEREOF |
摘要 |
The present invention provides moieties that bind to the asymmetric contact interface of a receptor tyrosine kinase (RTK), wherein the moieties inhibit ligand induced trans autophosphorylation of the RTK. The present invention also provides methods of treating or preventing an RTK-associated disease and methods for identifying moieties that bind to an asymmetric contact interface of an RTK.
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申请公布号 |
CA2786276(A1) |
申请公布日期 |
2011.07.21 |
申请号 |
CA20112786276 |
申请日期 |
2011.01.13 |
申请人 |
YALE UNIVERSITY |
发明人 |
BAE, JAE HYUN;LAX, IRIT;SCHLESSINGER, JOSEPH |
分类号 |
A61K38/17;C07K16/00 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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