发明名称 |
REPROGRAMMING BLOOD CELLS TO PLURIPOTENT AND MULTIPOTENT STEM CELLS |
摘要 |
The present invention is based on the seminal discovery that cord blood (CB) and adult bone marrow (BM) CD34+ cells can be reprogrammed to early stem cells. The invention provides the reprogramming of CB and adult bone marrow (BM) CD34+ cells from subjects without any pre-treatment. Provided are methods for reprogramming blood cells of a subject. Also provided are methods of disease modeling and methods of generating subject- specific differentiated cells. In addition, the invention provides methods of identifying an agent that alters a function of subject-specific differentiated cells as well as isolated pluripotent or multipotent stem cells reprogrammed from blood cells. |
申请公布号 |
WO2011032166(A3) |
申请公布日期 |
2011.07.21 |
申请号 |
WO2010US48810 |
申请日期 |
2010.09.14 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;CHENG, LINZHAO |
发明人 |
CHENG, LINZHAO |
分类号 |
C12N5/0789;C12N5/10;C12N15/85 |
主分类号 |
C12N5/0789 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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