METHODS FOR MODULATING SKELETAL REMODELING AND PATTERNING BY MODULATING SHN2 ACTIVITY, SHN3 ACTIVITY, OR SHN2 AND SHN3 ACTIVITY IN COMBINATION

摘要

This invention is based, at least in part, on the discovery that Shn2 and Shn3 play an important role in skeletal remodeling and skeletal patterning. Accordingly, the present inventon provides methods for identifying medulators of Shn2 activity and methods for modulating bone formation and mineralization and Shn2-associated disorders using agents that modulate Shn2 expression and/or activity, in addition to methods for modulating Shn2 and Shn3.