发明名称 |
METHODS FOR PREPARATION OF LIPID-ENCAPSULATED THERAPEUTIC AGENTS |
摘要 |
Fully lipid-encapsulated therapeutic agent particles of a charged therapeutic agent are prepared by combining a lipid composition containing preformed lipid vesicles, a charged therapeutic agent, and a destabilizing agent to form a mixture of preformed vesicles and therapeutic agent in a destabilizing solvent. The destabilizing solvent is effective to destabilize the membrane of the preformed lipid vesicles without disrupting the vesicles. The resulting mixture is incubated for a period of time sufficient to allow the encapsulation of the therapeutic agent within the preformed lipid vesicles. The destabilizing agent is then removed to yield fully lipid-encapsulated therapeutic agent particles. The preformed lipid vesicles comprise a charged lipid which has a charge which is opposite to the charge of the charged therapeutic agent and a modified lipid having a steric barrier moiety for control of aggregation.
|
申请公布号 |
US2011177130(A1) |
申请公布日期 |
2011.07.21 |
申请号 |
US20100871537 |
申请日期 |
2010.08.30 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
MAURER NORBERT;WONG KIM F.;CULLIS PIETER R. |
分类号 |
A61K9/00;A61K48/00;A61P43/00 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|