PATTERNED SURFACES AND METHODS OF USE FOR STEM CELL CULTURE

摘要

Nanopatterned surfaces which provide for improved cell growth including improved stem cell differentiation. The patterned surfaces can comprise an array of fields of biologically active moieties and can be controlled by parameters which include the pitch between the fields and the size of the fields. Nanopatterning can be carried out with use of dip pen nanolithographic printing, microcontact printing, and nanoimprint lithography. Patterning can be carried out on surfaces over large areas, with good homogeneity, and/or using edge-to-edge methods.