发明名称 |
Heterocyclic aspartyl protease inhibitors, preparation and use thereof |
摘要 |
<p>Compounds having the structural formula
or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein R 1 ,R 3 and R 4 are variables defined in the specification. The compounds function as aspartyl protease inhibitors and are useful in the treatment of cardiovascular diseases, cognitive and neurodegenerative diseases, and as inhibitors of the Human Immunodeficiency Virus, plasmepsins, cathepsin D and protozoal enzymes.</p> |
申请公布号 |
EP2345411(A1) |
申请公布日期 |
2011.07.20 |
申请号 |
EP20110157371 |
申请日期 |
2006.06.12 |
申请人 |
SCHERING CORPORATION;PHARMACOPEIA, LLC |
发明人 |
STAMFORD, ANDREW;LI, GUOQING;GREENLEE, WILLIAM, J;ZHU, ZHAONING;MCKITTRICK, BRIAN;MAZZOLA, ROBERT;HUANG, YING;GUO, TAO;LE THUY, X. H.;QIAN, GANG;SHAO, YUEFEI |
分类号 |
A61K31/519;A61K31/4035;A61P9/00;A61P25/28;A61P31/18;A61P33/00;C07D471/04;C07D487/04 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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