Compositions and methods for siRNA inhibition of angiogenesis

摘要

The present invention relates to RNA interference using small interfering RNAs (siRNAs) which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt1 and Flk-I/KDR and which inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.