发明名称 |
Angiostatin and method of use for inhibition of angiogenesis |
摘要 |
<p>The present invention comprises an endothelial inhibitor and method of use therefor. The endothelial inhibitor is a protein isolated from the blood or urine that is eluted as a single peak from C4-reverse phase high performance liquid chromatography. The endothelial inhibitor is a molecule comprising a protein having a molecular weight of between approximately 38 kilodaltons and 45 kilodaltons as determined by reducing polyacrylamide gel electrophoresis and having an amino acid sequence substantially similar to that of a murine plasminogen fragment beginning at amino acid number 98 of a murine plasminogen molecule.</p> |
申请公布号 |
EP1783215(B1) |
申请公布日期 |
2011.07.20 |
申请号 |
EP20070003963 |
申请日期 |
1995.04.26 |
申请人 |
THE CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
O'REILLY, MICHAEL S.;FOLKMAN, JUDAH M.;SIM, KIM LEE;CAO, YIHAI |
分类号 |
C12N9/68;C12N15/09;A61K35/76;A61K38/00;A61K38/43;A61K38/48;A61K48/00;A61P9/00;A61P27/02;A61P29/00;A61P35/00;C07H21/04;C07K14/47;C12N5/10;C12N15/57;C12P21/02;C12P21/08;C12Q1/02;G01N33/15;G01N33/50;G01N33/574;G01N33/68 |
主分类号 |
C12N9/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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